Endocrine Abstracts

While the hypothalamo-pituitary axis is known to contain high levels of basic FGF (FGF2) and its high affinity receptor FGFR1, the physiological role of FGF2 in this region needs elucidation. Here, we demonstrate that FGF2 and arginine vasopressin (AVP) co-localize within the cytoplasm of nearly all supraoptic and paraventricular magnocellular neurons of human hypothalamus as well as the axonal processes of the neurohypophysis. High-resolution confocal imaging indicates that F...